4597/10 | Tocris Bioscience 4597/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4597/10

catalog :

4597/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Schmidt E, Narangoda C, Nörenberg W, Egawa M, Rössig A, Leonhardt M, et al. Structural mechanism of TRPM7 channel regulation by intracellular magnesium. Cell Mol Life Sci. 2022;79:225 pubmed publisher
Souza Bomfim G, Costiniti V, Li Y, Idaghdour Y, Lacruz R. TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium. 2020;87:102187 pubmed publisher
Tian Y, Yang T, Yu S, Liu C, He M, Hu C. Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. J Cell Mol Med. 2018;22:6327-6337 pubmed publisher
Ferioli S, Zierler S, Zaißerer J, Schredelseker J, Gudermann T, Chubanov V. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP. Sci Rep. 2017;7:8806 pubmed publisher

product information

master code :

4597

SKU :

4597/10

product name :

NS 8593 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

299.8

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 M for SK1, SK2 and SK3 respectively at 0.5 M Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.

top caption :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

extended description :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

chemical name text :

N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride

formula :

C17H17N3.HCl

cas num :

875755-24-1

USD :

267 USD

product details :

Selective negative modulator of KCa2 (SK) channels; inhibits SK currents

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage