4596/10 | Tocris Bioscience 4596/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4596/10

catalog :

4596/10

quantity :

10 mg (also 50 mg)

price :

250 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Kalxdorf M, Günthner I, Becher I, Kurzawa N, Knecht S, Savitski M, et al. Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane. Nat Methods. 2021;18:84-91 pubmed publisher
Harms M, Gilg A, St xe4 ndker L, Beer A, Mayer B, Rasche V, et al. Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Sci Rep. 2020;10:16036 pubmed publisher
Soave M, Heukers R, Kellam B, Woolard J, Smit M, Briddon S, et al. Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies. Cell Chem Biol. 2020;27:1250-1261.e5 pubmed publisher
. Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4. Mol Pharmacol. 2020;98:72-87 pubmed publisher
White C, Caspar B, Vanyai H, Pfleger K, Hill S. CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. Cell Chem Biol. 2020;27:499-510.e7 pubmed publisher
Smith N, Rodero M, Bekaddour N, Bondet V, Ruiz Blanco Y, Harms M, et al. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Sci Adv. 2019;5:eaav9019 pubmed publisher
Rosenberg E, Harrison R, Tsou L, Drucker N, Humphries B, Rajasekaran D, et al. Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant. Cell Chem Biol. 2019;26:662-673.e7 pubmed publisher
Van Hout A, D huys T, Oeyen M, Schols D, Van Loy T. Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors. PLoS ONE. 2017;12:e0176057 pubmed publisher

product information

master code :

4596

SKU :

4596/10

product name :

IT1t dihydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent CXCR4 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

479.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

top caption :

Potent CXCR4 antagonist

extended description :

Potent CXCR4 antagonist

chemical name text :

N,N -Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride

formula :

C21H34N4S2.2HCl

formula text :

C21H34N4S2.2HCl

cas num :

1092776-63-0

USD :

250 USD

product details :

Potent CXCR4 antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage