GSK J4 | Tocris Bioscience 4594 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK J4

catalog :

4594

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Backe M, Jin C, Andreone L, Sankar A, Agger K, Helin K, et al. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis. J Diabetes Res. 2019;2019:5451038 pubmed publisher
Lin C, Hsu Y, Huang Y, Shih Y, Wang C, Chiang W, et al. A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO Mol Med. 2019;11: pubmed publisher
Bayo J, Tran T, Wang L, Peña Llopis S, Das A, Martinez E. Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. Cell Rep. 2018;25:1040-1050.e5 pubmed publisher
Ma K, Hung H, Svaren J. Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury. J Neurosci. 2016;36:9135-47 pubmed publisher
Palomer E, Carretero J, BenvegnÃ¹ S, Dotti C, Martin M. Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons. Nat Commun. 2016;7:11081 pubmed publisher
Pan D, Huang L, Zhu L, Zou T, Ou J, Zhou W, et al. Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity. Dev Cell. 2015;35:568-583 pubmed publisher
Kang S, Kim S, Chai J, Kim S, Won K, Lee Y, et al. Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation. PLoS ONE. 2015;10:e0135276 pubmed publisher
Aspuria P, Lunt S, VÃ¤remo L, Vergnes L, Gozo M, Beach J, et al. Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism. Cancer Metab. 2014;2:21 pubmed publisher
Perrigue P, Silva M, Warden C, Feng N, Reid M, Mota D, et al. The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res. 2015;13:636-50 pubmed publisher
Carey B, Finley L, Cross J, Allis C, Thompson C. Intracellular Î±-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518:413-6 pubmed publisher
Petruk S, Black K, Kovermann S, Brock H, Mazo A. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun. 2013;4:2841 pubmed publisher

product information

brand :

Tocris

master code :

4594

SKU :

4594/10

product name :

GSK J4

description :

Histone KDM inhibitor; cell permeable

target :

Histone Demethylase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

417.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 M for the inhibition of TNF release). Cell permeable. Ethyl ester derivative of GSK J1 . . Negative Control also available.

catalog number base :

4594

product keywords :

GSKJ4 histone demethylases inhibitors inhibits UTX JMJD3 KDM6 H3K27 KDMs proinflammatory macrophages tnf alpha tnfa anti-inflammatory epigenetics Histone Demethylases 4594,

extended description :

Histone KDM inhibitor; cell permeable

chemical name text :

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]- -alanine ethyl ester

formula :

C 24 H 27 N 5 O 2

formula text :

C24H27N5O2

cas num :

1373423-53-0

2020 USD :

207

2021 USD :

212 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage