GSK J1 | Tocris Bioscience 4593 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK J1

catalog :

4593

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang Y, et al. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun. 2016;7:11278 pubmed publisher
Aspuria P, Lunt S, VÃ¤remo L, Vergnes L, Gozo M, Beach J, et al. Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism. Cancer Metab. 2014;2:21 pubmed publisher

product information

brand :

Tocris

master code :

4593

SKU :

4593/10

product name :

GSK J1

description :

Potent JMJD3/UTX inhibitor

target :

Histone Demethylase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

389.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 20 M), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 M. . Ethyl ester derivative and Negative Control also available.

catalog number base :

4593

product keywords :

GSKJ1 histone demethylases inhibitors inhibits UTX JMJD3 H3K27 epigenetics jumonji demethylation sgc Histone Demethylases 4593,

extended description :

Potent JMJD3/UTX inhibitor

chemical name text :

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]- -alanine

formula :

C 22 H 23 N 5 O 2

formula text :

C22H23N5O2

cas num :

1373422-53-7

2020 USD :

216

2021 USD :

216 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage