4593/10 | Tocris Bioscience 4593/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4593/10

catalog :

4593/10

quantity :

10 mg (also 50 mg)

price :

258 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
D Oto A, Fang J, Jin H, Xu B, Singh S, Mullasseril A, et al. KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma. Nat Commun. 2021;12:7204 pubmed publisher
Kang S, Long K, Wang S, Sada A, Tumbar T. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin. Stem Cell Reports. 2020;14:34-48 pubmed publisher
Vogel F, Bordag N, Zügner E, Trajkovic Arsic M, Chauvistré H, Shannan B, et al. Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells. J Invest Dermatol. 2019;: pubmed publisher
Lee J, Kang S, Lilja K, Colletier K, Scheitz C, Zhang Y, et al. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis. Nat Commun. 2016;7:11278 pubmed publisher
Aspuria P, Lunt S, VÃ¤remo L, Vergnes L, Gozo M, Beach J, et al. Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism. Cancer Metab. 2014;2:21 pubmed publisher

product information

master code :

4593

SKU :

4593/10

product name :

GSK J1

unit size :

10 mg (also 50 mg)

description :

Potent JMJD3/UTX inhibitor

target :

Histone Demethylase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

389.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and 53 nM respectively). Also inhibits KDM5B, KDM5C and KDM5A (IC50 values are 170, 550 and 6,800 nM respectively). Exhibits no activity against a panel of other histone demethylases (IC50 20 M), and displays no significant inhibitory activity against 100 protein kinases at a concentration of 30 M. . Ethyl ester derivative and Negative Control also available.

top caption :

Potent JMJD3/UTX inhibitor

extended description :

Potent JMJD3/UTX inhibitor

chemical name text :

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]- -alanine

formula :

C22H23N5O2

formula text :

C22H23N5O2

cas num :

1373422-53-7

USD :

258 USD

product details :

Potent JMJD3/UTX inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage