4583/50 | Tocris Bioscience 4583/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4583/50

catalog :

4583/50

quantity :

50 mg

price :

68 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhang J, Sharma D, Dinabandhu A, Sanchez J, Applewhite B, Jee K, et al. Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice. J Clin Invest. 2023;133: pubmed publisher
Fletcher S, Maddock H, James R, Wallis R, Gharanei M. The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles. Sci Rep. 2020;10:5258 pubmed publisher
Griffith T, Docter T, Lumpkin E. Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci. 2019;39:7086-7101 pubmed publisher
Wang P, Wan W, Xiong S, Wang J, Zou D, Lan C, et al. HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels. Sci Rep. 2017;7:7965 pubmed publisher
Wang P, Lan C, Xiong S, Zhao X, Shan Y, Hu R, et al. HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget. 2017;8:28074-28092 pubmed publisher

product information

master code :

4583

SKU :

4583/50

product name :

Digoxin

unit size :

50 mg

description :

Na+/K+ ATPase inhibitor

target :

Na+/K+ ATPase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

780.94

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Digoxin is an inhibits membrane-bound -subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 M).

top caption :

Na+/K+ ATPase inhibitor

extended description :

Na+/K+ ATPase inhibitor

chemical name text :

4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetra

formula :

C41H64O14

formula text :

C41H64O14

cas num :

20830-75-5

USD :

68 USD

product details :

Na+/K+ ATPase inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage