PS 1145 dihydrochloride | Tocris Bioscience 4569 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PS 1145 dihydrochloride

catalog :

4569

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gari H, Degala G, Lucia M, Lambert J. Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth. Oncogenesis. 2016;5:e255 pubmed publisher

product information

brand :

Tocris

master code :

4569

SKU :

4569/10

product name :

PS 1145 dihydrochloride

description :

Selective IKK inhibitor; orally active

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

395.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective I B kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits I B- phosphorylation and NF B activation in HeLa cells. Inhibits NF B-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF- -induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF- production in vivo . Orally active.

catalog number base :

4569

product keywords :

PS1145 dihydrochloride selective IKK I B kinase IkappaB IKB inhibitors inhibits cytokines signaling NF B NFKappaB NFKB TNF-alpha TNF-a TNF- orally active IkB Kinase NF-kB/IkB 4569,

extended description :

Selective IKK inhibitor; orally active

chemical name text :

N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

formula :

C 17 H 11 ClN 4 O.2HCl

cas num :

1049743-58-9

2020 USD :

195

2021 USD :

199 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage