PS 1145 dihydrochloride | Tocris Bioscience 4569/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PS 1145 dihydrochloride

catalog :

4569/10

quantity :

10 mg (also 50 mg)

price :

247 USD

citations: 4

Reference
Wang A, Son M, Kenna E, Thom N, Tay S. NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli. Cell Rep. 2022;40:111159 pubmed publisher
Clanchy F, Huang Y, Ogbechi J, Darlington L, Williams R, Stone T. Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?. Front Immunol. 2022;13:832989 pubmed publisher
Mashukova A, Forteza R, Shah V, SALAS P. The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80. Mol Biol Cell. 2021;32:690-702 pubmed publisher
Gari H, Degala G, Lucia M, Lambert J. Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth. Oncogenesis. 2016;5:e255 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4569

SKU :

4569/10

product name :

PS 1145 dihydrochloride

Description :

Selective IKK inhibitor; orally active

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

395.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PS 1145 dihydrochloride is a selective I B kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits I B- phosphorylation and NF B activation in HeLa cells. Inhibits NF B-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF- -induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF- production in vivo . Orally active.

extended description :

Selective IKK inhibitor; orally active

chemical name text :

N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

formula :

C 17 H 11 ClN 4 O.2HCl

cas num :

1049743-58-9

USD :

247 USD

product details :

Selective IKK inhibitor; orally active

storage :

Store at +4°C