Topotecan hydrochloride | Tocris Bioscience 4562 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Topotecan hydrochloride

catalog :

4562

quantity :

10 mg (also 50 mg)

price :

64 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka Clift M, Barros A, et al. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun. 2019;10:87 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Pearson B, Simon J, McCoy E, Salazar G, Fragola G, Zylka M. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nat Commun. 2016;7:11173 pubmed publisher

product information

brand :

Tocris

master code :

4562

SKU :

4562/10

product name :

Topotecan hydrochloride

description :

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

target :

DNA Topoisomerase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

457.91

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable.

catalog number base :

4562

product keywords :

Topotecan HCl DNA topoisomerase inhibitors chemotherapeutics Mycn B-myb inhibits supplier antineoplastics orally available SK&F 104864-A DNA Topoisomerase 4562,

extended description :

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

chemical name text :

10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3 ,4 :6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

formula :

C 23 H 23 N 3 O 5 .HCl

formula text :

C23H23N3O5.HCl

cas num :

119413-54-6

2020 USD :

2021 USD :

64 USD

alt names :

SK F 104864-A

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage