Topotecan hydrochloride | Tocris Bioscience 4562/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Topotecan hydrochloride

catalog :

4562/10

quantity :

10 mg (also 50 mg)

price :

74 USD

citations: 6

Reference
Mathews J, Kuchling F, Baez Nieto D, Diberardinis M, Pan J, Levin M. Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma. Cancers (Basel). 2022;14: pubmed publisher
Tagal V, Roth M. Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs. Cancer Res. 2021;81:400-413 pubmed publisher
Balmus G, Pilger D, Coates J, Demir M, Sczaniecka Clift M, Barros A, et al. ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. Nat Commun. 2019;10:87 pubmed publisher
Drawnel F, Zhang J, Küng E, Aoyama N, Benmansour F, Araujo Del Rosario A, et al. Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery. Cell Chem Biol. 2017;24:624-634.e3 pubmed publisher
Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, et al. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017;8:22876-22893 pubmed publisher
Pearson B, Simon J, McCoy E, Salazar G, Fragola G, Zylka M. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nat Commun. 2016;7:11173 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4562

SKU :

4562/10

product name :

Topotecan hydrochloride

description :

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

target :

DNA Topoisomerase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

457.91

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.

product keywords :

Topotecan HCl DNA topoisomerase inhibitors chemotherapeutics Mycn B-myb inhibits supplier antineoplastics orally available U4 RNA splicing SK&F 104864-A DNA Topoisomerase DNA, RNA and Protein Synthesis 4562,

extended description :

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

chemical name text :

10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3 ,4 :6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

formula :

C23H23N3O5.HCl

formula text :

C23H23N3O5.HCl

cas num :

119413-54-6

USD :

USD 2025 :

74 USD

product details :

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

alt names :

SK F 104864-A