BIBN 4096 | Tocris Bioscience 4561 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIBN 4096

catalog :

4561

quantity :

10 mg

price :

338 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Pinho Ribeiro F, Baddal B, Haarsma R, O Seaghdha M, Yang N, Blake K, et al. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018;173:1083-1097.e22 pubmed publisher
Zhao J, Levy D. The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. Pain Rep. 2018;3:e632 pubmed publisher
Aubdool A, Graepel R, Kodji X, Alawi K, Bodkin J, Srivastava S, et al. TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun. 2014;5:5732 pubmed publisher
Engelstoft M, Park W, Sakata I, Kristensen L, Husted A, Osborne Lawrence S, et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2013;2:376-92 pubmed publisher

product information

brand :

Tocris

master code :

4561

SKU :

4561/10

product name :

BIBN 4096

description :

Potent and selective CGRP antagonist

target :

Calcitonin and Related Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

95%

observed molecular weight :

869.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors.

catalog number base :

4561

product keywords :

BIBN4096 migraine potent selective CGRP receptors antagonists calcitonin gene-related peptides Olcegepant Olcegepant Calcitonin and Related Receptors 4561,

extended description :

Potent and selective CGRP antagonist

chemical name text :

1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine

formula :

C 38 H 47 Br 2 N 9 O 5

formula text :

C38H47Br2N9O5

cas num :

204697-65-4

2020 USD :

321

2021 USD :

338 USD

alt names :

Olcegepant

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage