4561/10 | Tocris Bioscience 4561/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4561/10

catalog :

4561/10

quantity :

10 mg

price :

437 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Sun P, Li H, Xu Q, Zhang Z, Chen J, Shen Y, et al. Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons. Br J Pharmacol. 2023;180:1339-1361 pubmed publisher
Wee N, Novak S, Ghosh D, Root S, Dickerson I, Kalajzic I. Inhibition of CGRP signaling impairs fracture healing in mice. J Orthop Res. 2023;41:1228-1239 pubmed publisher
Nie L, Sun K, Gong Z, Li H, Quinn J, Wang M. Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway. Cells. 2022;11: pubmed publisher
Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, et al. Nociceptor neurons affect cancer immunosurveillance. Nature. 2022;611:405-412 pubmed publisher
Gao Z, Liu Y, Zhang L, Yang Z, Lv L, Wang S, et al. Nociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections. J Inflamm Res. 2022;15:3337-3353 pubmed publisher
xc1 valos Prado P, Landra Willm A, Verkest C, Ribera A, Chassot A, Baron A, et al. TREK channel activation suppresses migraine pain phenotype. iScience. 2021;24:102961 pubmed publisher
Norton C, Grunz Borgmann E, Hart M, Jones B, Franklin C, Boerman E. Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease. Am J Physiol Heart Circ Physiol. 2021;320:H1887-H1902 pubmed publisher
Moreira L, Takawale A, Hulsurkar M, Menassa D, Antanaviciute A, Lahiri S, et al. Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. 2020;587:460-465 pubmed publisher
Na H, Gan Q, Mcparland L, Yang J, Yao H, Tian H, et al. Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease. Neuropharmacology. 2020;168:108017 pubmed publisher
Driessen A, Farrell M, Dutschmann M, Stanic D, McGovern A, Mazzone S. Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits. Brain Struct Funct. 2018;223:4005-4022 pubmed publisher
Pinho Ribeiro F, Baddal B, Haarsma R, O Seaghdha M, Yang N, Blake K, et al. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018;173:1083-1097.e22 pubmed publisher
Zhao J, Levy D. The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. Pain Rep. 2018;3:e632 pubmed publisher
Potes C, Pestana A, Pontes M, Caramelo A, Neto F. Amylin modulates the formalin-induced tonic pain behaviours in rats. Eur J Pain. 2016;20:1741-1752 pubmed publisher
Aubdool A, Graepel R, Kodji X, Alawi K, Bodkin J, Srivastava S, et al. TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun. 2014;5:5732 pubmed publisher
Engelstoft M, Park W, Sakata I, Kristensen L, Husted A, Osborne Lawrence S, et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab. 2013;2:376-92 pubmed publisher

product information

master code :

4561

SKU :

4561/10

product name :

BIBN 4096

unit size :

10 mg

description :

Potent and selective CGRP antagonist

target :

Calcitonin and Related Receptor Antagonists

category :

Small Molecules

purity :

95%

observed molecular weight :

869.65

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIBN 4096 is a potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors. BIBN 4096 improves pain symptoms in a mouse migraine model.

top caption :

Potent and selective CGRP antagonist

extended description :

Potent and selective CGRP antagonist

chemical name text :

1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine

formula :

C38H47Br2N9O5

formula text :

C38H47Br2N9O5

cas num :

204697-65-4

USD :

437 USD

product details :

Potent and selective CGRP antagonist

alt names :

Olcegepant

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage