GNF 5837 | Tocris Bioscience 4559 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GNF 5837

catalog :

4559

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Tsai Y, Tseng L, Hsu C, Yang M, Chiu J, Shyr Y. Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer. PLoS ONE. 2017;12:e0178173 pubmed publisher

product information

brand :

Tocris

master code :

4559

SKU :

4559/10

product name :

GNF 5837

description :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

target :

Trk Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

535.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 M respectively). Orally bioavailable.

catalog number base :

4559

product keywords :

GNF5837 Trk receptors TrkA TrkB TrkC pan-Trk inhibitors inhibits antiproliferative Trk Receptors 4559,

extended description :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

chemical name text :

N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N -[2-fluoro-5-(trifluoromethyl)phenyl]urea

formula :

C 28 H 21 F 4 N 5 O 2

formula text :

C28H21F4N5O2

cas num :

1033769-28-6

2020 USD :

259

2021 USD :

270 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage