4559/10 | Tocris Bioscience 4559/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4559/10

catalog :

4559/10

quantity :

10 mg (also 50 mg)

price :

345 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Chou S, Li K, Huang M, Chen C, Lin King Y, Li G, et al. Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway. elife. 2021;10: pubmed publisher
Jeon M, Moon G, Kim S, Choi M, Oh Y, Kim D, et al. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. Br J Pharmacol. 2020;177:668-686 pubmed publisher
Tsai Y, Tseng L, Hsu C, Yang M, Chiu J, Shyr Y. Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer. PLoS ONE. 2017;12:e0178173 pubmed publisher
Shutov L, Warwick C, Shi X, Gnanasekaran A, Shepherd A, Mohapatra D, et al. The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. J Neurosci. 2016;36:5055-70 pubmed publisher

image

image 1 :

Cat.No. 4559 - GNF 5837 C28H21F4N5O2 CAS No. 1033769-28-6

product information

master code :

4559

SKU :

4559/10

product name :

GNF 5837

unit size :

10 mg (also 50 mg)

description :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

target :

Trk Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

535.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GNF 5837 is a potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 M respectively). Orally bioavailable.

top caption :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

extended description :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

chemical name text :

N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N -[2-fluoro-5-(trifluoromethyl)phenyl]urea

formula :

C28H21F4N5O2

formula text :

C28H21F4N5O2

cas num :

1033769-28-6

USD :

345 USD

product details :

Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage