EMPA | Tocris Bioscience 4558 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EMPA

catalog :

4558

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Beig M, Horiuchi J, Dampney R, Carrive P. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus. Clin Exp Pharmacol Physiol. 2015;42:1059-67 pubmed publisher
Guerreiro S, Florence C, Rousseau E, Hamadat S, Hirsch E, Michel P. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol Pharmacol. 2015;87:525-32 pubmed publisher

product information

brand :

Tocris

master code :

4558

SKU :

4558/10

product name :

EMPA

description :

Highly potent and selective OX2 antagonist; brain penetrant

target :

OX2 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

454.54

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent, selective OX2 receptor antagonist (IC50 values are 2.3 nM and 1900 nM for OX2 and OX1 respectively). Displays negligible or no inhibition of a panel of 80 receptors. Blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 values are 7.9 nM and 8.8 nM respectively); reverses orexin-B-induced hyperlocomotion in mice. Brain penetrant.

catalog number base :

4558

product keywords :

supplier orexin 2 receptor OX2 antagonists inhibits potent selective hyperlocomotion brain penetrant OX2 Receptor 4558,

extended description :

Highly potent and selective OX2 antagonist; brain penetrant

chemical name text :

N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide

formula :

C 23 H 26 N 4 O 4 S

formula text :

C23H26N4O4S

cas num :

680590-49-2

2020 USD :

234

2021 USD :

244 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage