4558/10 | Tocris Bioscience 4558/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4558/10

catalog :

4558/10

quantity :

10 mg

price :

313 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Elam H, Perez S, Donegan J, Lodge D. Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis. Transl Psychiatry. 2021;11:114 pubmed publisher
Flanigan M, Aleyasin H, Li L, Burnett C, Chan K, Leclair K, et al. Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nat Neurosci. 2020;23:638-650 pubmed publisher
Beig M, Horiuchi J, Dampney R, Carrive P. Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus. Clin Exp Pharmacol Physiol. 2015;42:1059-67 pubmed publisher
Guerreiro S, Florence C, Rousseau E, Hamadat S, Hirsch E, Michel P. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol Pharmacol. 2015;87:525-32 pubmed publisher

product information

master code :

4558

SKU :

4558/10

product name :

EMPA

unit size :

10 mg

description :

Highly potent and selective OX2 antagonist; brain penetrant

target :

OX2 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

454.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EMPA is a highly potent, selective OX2 receptor antagonist (IC50 values are 2.3 nM and 1900 nM for OX2 and OX1 respectively). Displays negligible or no inhibition of a panel of 80 receptors. Blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 values are 7.9 nM and 8.8 nM respectively); reverses orexin-B-induced hyperlocomotion in mice. Brain penetrant.

top caption :

Highly potent and selective OX2 antagonist; brain penetrant

extended description :

Highly potent and selective OX2 antagonist; brain penetrant

chemical name text :

N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide

formula :

C23H26N4O4S

formula text :

C23H26N4O4S

cas num :

680590-49-2

USD :

313 USD

product details :

Highly potent and selective OX2 antagonist; brain penetrant

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage