CP 690550 citrate | Tocris Bioscience 4556 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CP 690550 citrate

catalog :

4556

quantity :

10 mg (also 50 mg)

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, et al. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017;8:1457 pubmed publisher
Tactacan C, Phua Y, Liu L, Zhang L, Humphrey E, Cowley M, et al. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. Mol Cancer. 2015;14:139 pubmed publisher
Zhu Y, Brown J, Sag D, Zhang L, Suttles J. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages. J Immunol. 2015;194:584-94 pubmed publisher
Dowty M, Jesson M, Ghosh S, Lee J, Meyer D, Krishnaswami S, et al. Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther. 2014;348:165-73 pubmed publisher

product information

brand :

Tocris

master code :

4556

SKU :

4556/10

product name :

CP 690550 citrate

description :

Potent JAK inhibitor

target :

JAK Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

504.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent JAK inhibitor (IC50 values are 1, 20, and 112 nM for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models.

catalog number base :

4556

product keywords :

CP690550 immunosuppressants autoimmune antirheumatics rheumatoid arthritis pfizer JAK janus kinase JAK1 JAK2 JAK3 inhibitors inhibits Tofacitinib Tofacitinib citrate JAK Kinase 4556,

extended description :

Potent JAK inhibitor

chemical name text :

(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)- -oxo-1-piperidinepropanenitrile citrate

formula :

C 16 H 20 N 6 O.C 6 H 8 O 7

formula text :

C16H20N6O.C6H8O7

cas num :

540737-29-9

2020 USD :

188

2021 USD :

196 USD

alt names :

Tofacitinib citrate

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage