GC 1 | Tocris Bioscience 4554 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GC 1

catalog :

4554

quantity :

10 mg (also 50 mg)

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Balboa D, Saarimäki Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. elife. 2018;7: pubmed publisher
Gonzalez Hurtado E, Lee J, Choi J, Wolfgang M. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2018;7:45-56 pubmed publisher
Yao X, Su T, Verkman A. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun. 2016;4:42 pubmed publisher
Johansson L, Rudling M, Scanlan T, Lundåsen T, Webb P, Baxter J, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005;102:10297-302 pubmed

product information

brand :

Tocris

master code :

4554

SKU :

4554/10

product name :

GC 1

description :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

target :

Nuclear Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

328.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) and TR receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TR 1 and TR 1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

catalog number base :

4554

product keywords :

GC1 thryomimetic high affinity thyroid hormone receptor TR TRalpha TRbeta agonists T3 reverse cholesterol transport hypercholesterolaemia cellular proliferation Sobetirome Other Nuclear Receptors 4554,

extended description :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

chemical name text :

2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid

formula :

C 20 H 24 O 4

formula text :

C20H24O4

cas num :

211110-63-3

2020 USD :

188

2021 USD :

196 USD

alt names :

Sobetirome

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage