4554/10 | Tocris Bioscience 4554/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4554/10

catalog :

4554/10

quantity :

10 mg (also 50 mg)

price :

254 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Yuan B, Shi K, Zha J, Cai Y, Gu Y, Huang K, et al. Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis. 2023;14:51 pubmed publisher
Barahman M, Zhang W, Harris H, Aiyer A, Kabarriti R, Kinkhabwala M, et al. Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. J Hepatol. 2019;70:1170-1179 pubmed publisher
Balboa D, Saarimäki Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. elife. 2018;7: pubmed publisher
Gonzalez Hurtado E, Lee J, Choi J, Wolfgang M. Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2018;7:45-56 pubmed publisher
Saarimäki Vire J, Balboa D, Russell M, Saarikettu J, Kinnunen M, Keskitalo S, et al. An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep. 2017;19:281-294 pubmed publisher
Yao X, Su T, Verkman A. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun. 2016;4:42 pubmed publisher
Johansson L, Rudling M, Scanlan T, Lundåsen T, Webb P, Baxter J, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005;102:10297-302 pubmed

product information

master code :

4554

SKU :

4554/10

product name :

GC 1

unit size :

10 mg (also 50 mg)

description :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

target :

Nuclear Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

328.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) and TR receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TR 1 and TR 1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

top caption :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

extended description :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

chemical name text :

2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid

formula :

C20H24O4

formula text :

C20H24O4

cas num :

211110-63-3

USD :

254 USD

product details :

High affinity thyroid receptor (TR ) and TR agonist; thyromimetic

alt names :

Sobetirome

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage