Purmorphamine | Tocris Bioscience 4551 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Purmorphamine

catalog :

4551

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Hackland J, Shelar P, Sandhu N, Prasad M, Charney R, Gomez G, et al. FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision. Stem Cell Reports. 2019;12:920-933 pubmed publisher
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed publisher
Lang C, Campbell K, Ryan B, Carling P, Attar M, Vowles J, et al. Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell. 2019;24:93-106.e6 pubmed publisher
Kaindl J, Meiser I, Majer J, Sommer A, Krach F, Katsen Globa A, et al. Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Transl Med. 2019;8:247-259 pubmed publisher
Sheng C, Jungverdorben J, Wiethoff H, Lin Q, Flitsch L, Eckert D, et al. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun. 2018;9:4047 pubmed publisher
Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, et al. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018;23:123-131.e6 pubmed publisher
Rajamani U, Gross A, Hjelm B, Sequeira A, Vawter M, Tang J, et al. Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses. Cell Stem Cell. 2018;22:698-712.e9 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher

product information

brand :

Tocris

master code :

4551

SKU :

4551/10

product name :

Purmorphamine

description :

Smo receptor agonist

target :

Smoothened Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

520.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Smoothened (Smo) receptor agonist (EC50 ~ 1 M). Induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

catalog number base :

4551

product keywords :

Smoothened Smo receptors agonists differentiation multipotent mesenchymal progenitor cells osteoblasts osteogenic Smoothened Receptors Mesenchymal Stem Cells Osteogenic Stem Cells 4551,

extended description :

Smo receptor agonist

chemical name text :

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

formula :

C 31 H 32 N 6 O 2

formula text :

C31H32N6O2

cas num :

483367-10-8

2020 USD :

216

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage