ML 133 hydrochloride | Tocris Bioscience 4549 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 133 hydrochloride

catalog :

4549

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Lively S, Lam D, Wong R, Schlichter L. Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. Front Cell Neurosci. 2018;12:115 pubmed publisher
Siddiqui T, Lively S, Schlichter L. Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation. 2016;13:66 pubmed publisher
Lam D, Schlichter L. Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Front Cell Neurosci. 2015;9:185 pubmed publisher

product information

brand :

Tocris

master code :

4549

SKU :

4549/10

product name :

ML 133 hydrochloride

description :

Kir2 channel blocker

target :

Inward Rectifier Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

313.82

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 M at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 300 M); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 M).

catalog number base :

4549

product keywords :

ML133 hydrochloride Kir2 Kir2.x Kir2.1 Kir2.6 Kir2.2 Kir2.3 inhibitors inhibits inward rectifier potassium channels IRK1 KCNJ2 IRK2 hIRK IRK3 hIRK2 Inward rectifier Potassium Channels 4549,

extended description :

Kir2 channel blocker

chemical name text :

N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride

formula :

C 19 H 19 NO.HCl

formula text :

C19H19NO.HCl

cas num :

1222781-70-5

2020 USD :

155

2021 USD :

160 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage