4549/10 | Tocris Bioscience 4549/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4549/10

catalog :

4549/10

quantity :

10 mg (also 50 mg)

price :

202 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Song B, Lee S, Kim C. Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model. Int J Mol Sci. 2021;22: pubmed publisher
Lively S, Lam D, Wong R, Schlichter L. Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels. Front Cell Neurosci. 2018;12:115 pubmed publisher
Lam D, Lively S, Schlichter L. Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration. J Neuroinflammation. 2017;14:166 pubmed publisher
Spencer N, Schilling T, Miralles F, Eder C. Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production. PLoS ONE. 2016;11:e0162497 pubmed publisher
Siddiqui T, Lively S, Schlichter L. Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation. 2016;13:66 pubmed publisher
Lam D, Schlichter L. Expression and contributions of the Kir2.1 inward-rectifier K(+) channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states. Front Cell Neurosci. 2015;9:185 pubmed publisher
Charolidi N, Schilling T, Eder C. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. PLoS ONE. 2015;10:e0128463 pubmed publisher

product information

master code :

4549

SKU :

4549/10

product name :

ML 133 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Kir2 channel blocker

target :

Inward Rectifier Potassium Channel Blockers

category :

Small Molecules

purity :

99%

observed molecular weight :

313.82

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 M at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Exhibits no effect on rKir1.1 (IC50 300 M); displays weak activity at hKir7.1 and rKir4.1 (IC50 values are 33 and 76 M).

top caption :

Kir2 channel blocker

extended description :

Kir2 channel blocker

chemical name text :

N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride

formula :

C19H19NO.HCl

formula text :

C19H19NO.HCl

cas num :

1222781-70-5

USD :

202 USD

product details :

Kir2 channel blocker

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage