E 64d | Tocris Bioscience 4545 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

E 64d

catalog :

4545

quantity :

1 mg

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, et al. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017;68:786-796.e6 pubmed publisher
Zhang P, Liu X, Li H, Chen Z, Yao X, Jin J, et al. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Sci Rep. 2017;7:3158 pubmed publisher

product information

brand :

Tocris

master code :

4545

SKU :

4545/1

product name :

E 64d

description :

Cathepsin inhibitor; interferes with autolysosomal digestion

target :

Synthetic Cathepsin Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

342.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. Also inhibits entry of SARS-Cov-2 (COVID-19) into Caco-2 and Vero cells in combination with Camostat mesylate (Cat.No. 3193) in vitro .

catalog number base :

4545

product keywords :

lysosomal proteases inhibitors inhibits cathepsins autophagy autolysosomal digestion E64d COVID-19 SARS-Cov-2 Autophagy Calcium-Sensitive Proteases Cathepsin Coronavirus 4545,

extended description :

Cathepsin inhibitor; interferes with autolysosomal digestion

chemical name text :

(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester

formula :

C 17 H 30 N 2 O 5

formula text :

C17H30N2O5

cas num :

88321-09-9

2020 USD :

166

2021 USD :

173 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage