4545/1 | Tocris Bioscience 4545/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4545/1

catalog :

4545/1

quantity :

1 mg

price :

226 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Chen D, Turcinovic J, Feng S, Kenney D, Chin C, Choudhary M, et al. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience. 2023;26:106634 pubmed publisher
Meng B, Datir R, Choi J, Bradley J, Smith K, Lee J, et al. SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity. Cell Rep. 2022;40:111220 pubmed publisher
Sun L, Wang Y, Wang X, Navarro Corcuera A, Ilyas S, Jalan Sakrikar N, et al. PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II. Cell Rep. 2022;38:110349 pubmed publisher
Knight W, Cao Y, Dillon P, Song K. A simple protocol to produce mature human-induced pluripotent stem cell-derived cardiomyocytes. STAR Protoc. 2021;2:100912 pubmed publisher
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, et al. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017;68:786-796.e6 pubmed publisher
Zhang P, Liu X, Li H, Chen Z, Yao X, Jin J, et al. TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Sci Rep. 2017;7:3158 pubmed publisher

product information

master code :

4545

SKU :

4545/1

product name :

E 64d

unit size :

1 mg

description :

Cathepsin inhibitor; interferes with autolysosomal digestion

target :

Synthetic Cathepsin Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

342.43

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

E 64d is an inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. Also inhibits entry of SARS-Cov-2 (COVID-19) into Caco-2 and Vero cells in combination with Camostat mesylate (Cat.No. 3193) in vitro .

top caption :

Cathepsin inhibitor; interferes with autolysosomal digestion

extended description :

Cathepsin inhibitor; interferes with autolysosomal digestion

chemical name text :

(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester

formula :

C17H30N2O5

formula text :

C17H30N2O5

cas num :

88321-09-9

USD :

226 USD

product details :

Cathepsin inhibitor; interferes with autolysosomal digestion

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage