YM 244769 | Tocris Bioscience 4544 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YM 244769

catalog :

4544

quantity :

10 mg (also 50 mg)

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
O Donnell J, Jackson J, Robinson M. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 2016;36:7109-27 pubmed publisher

product information

brand :

Tocris

master code :

4544

SKU :

4544/10

product name :

YM 244769

description :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

target :

Na+/Ca2+ Exchanger Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

516.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

catalog number base :

4544

product keywords :

YM244769 anti-ischemic anti-ischaemic hypoxia/reoxygenation injury neuroprotective Na+ Ca2+ exchangers NCX NCX3 NCX2 NCX1 inhibitors inhibits reverse mode selective Na+/Ca2+ Exchanger 4544,

extended description :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

chemical name text :

N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

formula :

C 26 H 22 FN 3 O 3 .2HCl

formula text :

C26H22FN3O3.2HCl

cas num :

1780390-65-9

2020 USD :

185

2021 USD :

191 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage