4544/10 | Tocris Bioscience 4544/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4544/10

catalog :

4544/10

quantity :

10 mg (also 50 mg)

price :

215 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Jackson J, Krizman E, Takano H, Lee M, Choi G, Putt M, et al. Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci. 2022;16:831061 pubmed publisher
Liu Z, Cheng Q, Ma X, Song M. Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells. Int J Mol Sci. 2022;23: pubmed publisher
Williams D, Mehrabian M, Arshad H, Eid S, Sackmann C, Zhao W, et al. The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. PLoS ONE. 2021;16:e0258682 pubmed publisher
Hu H, Wang S, Wang Y, Liu Y, Feng X, Shen Y, et al. Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol. 2019;176:2691-2707 pubmed publisher
O Donnell J, Jackson J, Robinson M. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 2016;36:7109-27 pubmed publisher

product information

master code :

4544

SKU :

4544/10

product name :

YM 244769

unit size :

10 mg (also 50 mg)

description :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

target :

Na+/Ca2+ Exchanger Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

516.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

top caption :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

extended description :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

chemical name text :

N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride

formula :

C26H22FN3O3.2HCl

formula text :

C26H22FN3O3.2HCl

cas num :

1780390-65-9

USD :

215 USD

product details :

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage