chemical

SGC 0946

4541

2 mg

75 USD

4541

4541/2

SGC 0946

Highly potent and selective DOT1L inhibitor; cell permeable

Lysine Methyltransferase Inhibitors

Small Molecules

2 mg

99%

618.57

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Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1 . . To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website .

4541

SGC0946 epigenetics DOT1L histone protein methyltransferase PKMTs H3K79me potent selective inhibitors inhibits leukemia MLL target genes Lysine Methyltransferases Other Lysine Methyltransferases 4541,

Highly potent and selective DOT1L inhibitor; cell permeable

1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea

C 28 H 40 BrN 7 O 4

C28H40BrN7O4

1561178-17-3

75

75 USD

Store at -20°C