4541/2 | Tocris Bioscience 4541/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4541/2

catalog :

4541/2

quantity :

2 mg

price :

81 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed publisher

product information

master code :

4541

SKU :

4541/2

product name :

SGC 0946

unit size :

2 mg

description :

Highly potent and selective DOT1L inhibitor; cell permeable

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

618.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SGC 0946 is a highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1 . . To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website . . For more information about how SGC 0946 may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

top caption :

Highly potent and selective DOT1L inhibitor; cell permeable

extended description :

Highly potent and selective DOT1L inhibitor; cell permeable

chemical name text :

1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea

formula :

C28H40BrN7O4

formula text :

C28H40BrN7O4

cas num :

1561178-17-3

USD :

81 USD

product details :

Highly potent and selective DOT1L inhibitor; cell permeable

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage