product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
4539/10
catalog :
4539/10
quantity :
10 mg (also 50 mg)
price :
233 USD
more info or order :
citations: 19
Reference
Choi J, MacDonald C, Gandhi N, DAS G, Repasky E, Mohammadpour H. Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis. STAR Protoc. 2022;3:101389 pubmed publisher
Mohammadpour H, MacDonald C, McCarthy P, Abrams S, Repasky E. β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME. Cell Rep. 2021;37:109883 pubmed publisher
Vickers S, Saporito D, Leonardi R. Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes. J Vis Exp. 2021;: pubmed publisher
Vilks K, Videja M, Makrecka Kuka M, Katkevics M, Sevostjanovs E, Grandane A, et al. Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism. Int J Mol Sci. 2021;22: pubmed publisher
Sveidahl Johansen O, Ma T, Hansen J, Markussen L, Schreiber R, Reverte Salisa L, et al. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021;184:3502-3518.e33 pubmed publisher
Acoba M, Alpergin E, Renuse S, Fernández Del Río L, Lu Y, Khalimonchuk O, et al. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep. 2021;34:108869 pubmed publisher
Ceco E, Celli D, Weinberg S, Shigemura M, Welch L, Volpe L, et al. Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation. Front Physiol. 2020;11:630910 pubmed publisher
Zhang L, Avery J, Yin A, Singh A, Cliff T, Yin H, et al. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State. Cell Stem Cell. 2020;27:784-797.e11 pubmed publisher
Papay R, Perez D. α1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes. J Recept Signal Transduct Res. 2021;41:138-144 pubmed publisher
Chandra P, He L, Zimmerman M, Yang G, Köster S, Ouimet M, et al. Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. MBio. 2020;11: pubmed publisher
Ramstead A, Wallace J, Lee S, Bauer K, Tang W, Ekiz H, et al. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep. 2020;30:2889-2899.e6 pubmed publisher
Corbet C, Bastien E, Santiago de Jesus J, Dierge E, Martherus R, Vander Linden C, et al. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nat Commun. 2020;11:454 pubmed publisher
Tibbitt C, Stark J, Martens L, Ma J, Mold J, Deswarte K, et al. Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells. Immunity. 2019;: pubmed publisher
Weir H, Yao P, Huynh F, Escoubas C, Gonçalves R, Burkewitz K, et al. Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell Metab. 2017;26:884-896.e5 pubmed publisher
Schell J, Wisidagama D, Bensard C, Zhao H, Wei P, Tanner J, et al. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017;19:1027-1036 pubmed publisher
Wilhelm C, Harrison O, Schmitt V, Pelletier M, Spencer S, Urban J, et al. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection. J Exp Med. 2016;213:1409-18 pubmed publisher
Cordonier E, Jarecke S, Hollinger F, Zempleni J. Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells. Eur J Pharmacol. 2016;780:202-8 pubmed publisher
Han A, Bennett N, MacDonald A, Johnstone M, Whelan J, Donohoe D. Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. J Cell Physiol. 2016;231:1804-13 pubmed publisher
Patel A, Johansson G, Colbert M, Dasgupta B, Ratner N. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro Oncol. 2015;17:1599-608 pubmed publisher
product information
master code :
4539
SKU :
4539/10
product name :
(R)-(+)-Etomoxir sodium salt
unit size :
10 mg (also 50 mg)
description :
Carnitine palmitoyltransferase I (CPT1) inhibitor
target :
Other Transferase Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
320.74
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( R )-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits -oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
top caption :
Carnitine palmitoyltransferase I (CPT1) inhibitor
extended description :
Carnitine palmitoyltransferase I (CPT1) inhibitor
chemical name text :
(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
formula :
C15H18ClNaO4
formula text :
C15H18ClNaO4
cas num :
828934-41-4
USD :
233 USD
product details :
Carnitine palmitoyltransferase I (CPT1) inhibitor
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK