T16Ainh - A01 | Tocris Bioscience 4538 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

T16Ainh - A01

catalog :

4538

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Kusuda Y, Kondo Y, Miyagi Y, Munemasa T, Hori Y, Aonuma F, et al. Long-term dexamethasone treatment diminishes store-operated Ca2+ entry in salivary acinar cells. Int J Oral Sci. 2019;11:1 pubmed publisher
Zhang W, Schmelzeisen S, Parthier D, Frings S, MÃ¶hrlen F. Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS ONE. 2015;10:e0142160 pubmed publisher
Pineda Farias J, BarragÃ¡n Iglesias P, Loeza Alcocer E, Torres LÃ³pez J, Rocha GonzÃ¡lez H, PÃ©rez Severiano F, et al. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats. Mol Pain. 2015;11:41 pubmed publisher
Zhang Y, Wang X, Wang H, Jiao J, Li Y, Fan E, et al. TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients. Allergy Asthma Immunol Res. 2015;7:367-75 pubmed publisher
Bijos D, Drake M, Vahabi B. Anoctamin-1 in the juvenile rat urinary bladder. PLoS ONE. 2014;9:e106190 pubmed publisher
Bill A, Hall M, Borawski J, Hodgson C, Jenkins J, Piechon P, et al. Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics. J Biol Chem. 2014;289:11029-41 pubmed publisher
Harper M, Poole A. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. Cell Death Dis. 2013;4:e969 pubmed publisher
Jeon J, Paik S, Chun M, Oh U, Kim I. Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS ONE. 2013;8:e67989 pubmed publisher

product information

brand :

Tocris

master code :

4538

SKU :

4538/10

product name :

T16Ainh - A01

description :

Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor

target :

Calcium-activated Chloride Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

416.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 M in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro .

catalog number base :

4538

product keywords :

T16Ainh-A01 supplier ca2+ calcium activated sensitive chloride Cl- channels CaCC transmembrane TMEM16A inhibitors inhibits antiproliferative antitumor Ca2+-Activated Chloride Channels 4538,

extended description :

Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor

chemical name text :

2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

formula :

C 19 H 20 N 4 O 3 S 2

formula text :

C19H20N4O3S2

cas num :

552309-42-9

2020 USD :

154

2021 USD :

159 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage