Ciliobrevin A | Tocris Bioscience 4529 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ciliobrevin A

catalog :

4529

quantity :

25 mg

price :

386 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Poon J, Fries A, Wessel G, Yajima M. Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Commun. 2019;10:3779 pubmed publisher
Conzemius R, Ganjian H, Blaas D, Fuchs R. ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. J Virol. 2016;90:7934-42 pubmed publisher
Shin J, Bae D, Kim E, Kim H, Park S, Jo Y, et al. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul). 2015;23:327-32 pubmed publisher

product information

brand :

Tocris

master code :

4529

SKU :

4529/25

product name :

Ciliobrevin A

description :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

358.18

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 M) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

catalog number base :

4529

product keywords :

CiliobrevinA supplier hedgehog Hh pathway antagonists blocks inhibits inhibitors Smo smoothened patched ciliogenesis cilia microtubules dynein cytoplasmic AAA+ ATPase HPI-4 HPI-4 Hedgehog Signaling Stem Cell Signaling Other ATPases 4529,

extended description :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

chemical name text :

2,4-Dichloro- -(3,4-4-oxo-2(1H)-quinazolinylidene)- -oxobenzenepropanenitrile

formula :

C 17 H 9 Cl 2 N 3 O 2

formula text :

C17H9Cl2N3O2

cas num :

302803-72-1

2020 USD :

374

2021 USD :

386 USD

alt names :

HPI-4

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage