4529/5 | Tocris Bioscience 4529/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4529/5

catalog :

4529/5

quantity :

5 mg (also 25 mg)

price :

130 USD

citations: 7

Reference
Magupalli V, Negro R, Tian Y, Hauenstein A, Di Caprio G, Skillern W, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369: pubmed publisher
Bae J, Kang G, Min S, Jo D, Jung Y, Kim K, et al. Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis. 2019;10:952 pubmed publisher
Poon J, Fries A, Wessel G, Yajima M. Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Commun. 2019;10:3779 pubmed publisher
Zhou Y, Su J, Samuel C, Ma D. Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles. J Virol. 2019;93: pubmed publisher
Zhang X, Ren J, Wang J, Li S, Zou Q, Gao N. Receptor-mediated endocytosis generates nanomechanical force reflective of ligand identity and cellular property. J Cell Physiol. 2017;: pubmed publisher
Conzemius R, Ganjian H, Blaas D, Fuchs R. ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. J Virol. 2016;90:7934-42 pubmed publisher
Shin J, Bae D, Kim E, Kim H, Park S, Jo Y, et al. Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul). 2015;23:327-32 pubmed publisher

product information

master code :

4529

SKU :

4529/5

product name :

Ciliobrevin A

unit size :

5 mg (also 25 mg)

description :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

358.18

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 M) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.

top caption :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

extended description :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

chemical name text :

2,4-Dichloro- -(3,4-4-oxo-2(1H)-quinazolinylidene)- -oxobenzenepropanenitrile

formula :

C17H9Cl2N3O2

formula text :

C17H9Cl2N3O2

cas num :

302803-72-1

USD :

130 USD

product details :

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

alt names :

HPI-4

storage :

Store at +4░C