4528/10 | Tocris Bioscience 4528/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4528/10

catalog :

4528/10

quantity :

10 mg

price :

385 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Fumagalli A, Heuninck J, Pizzoccaro A, Moutin E, Koenen J, Seveno M, et al. The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication. Nat Commun. 2020;11:4855 pubmed publisher
Piotrowska A, Rojewska E, Pawlik K, Kreiner G, Ciechanowska A, Makuch W, et al. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3418-3437 pubmed publisher
Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, et al. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. Nat Commun. 2016;7:13885 pubmed publisher

product information

master code :

4528

SKU :

4528/10

product name :

(+/-)-NBI 74330

unit size :

10 mg

description :

Potent and selective CXCR3 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

605.58

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( )-NBI 74330 is a potent and selective CXCR3 antagonist; potently inhibits 125I-CXCL10 binding to CXCR3 (pKi = 8.13). Inhibits calcium mobilization in response to CXCL11 and CXCL10 in RBL cells. Exhibits no significant effect on chemotaxis induced by CXCR4 or CCR7. Displays a five-fold greater affinity for CXCR3 than ( )-AMG 487 . . This product is racemic.

top caption :

Potent and selective CXCR3 antagonist

extended description :

Potent and selective CXCR3 antagonist

chemical name text :

N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide

formula :

C32H27F4N5O3

formula text :

C32H27F4N5O3

cas num :

473722-68-8

USD :

385 USD

product details :

Potent and selective CXCR3 antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage