TC-I 15 | Tocris Bioscience 4527 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-I 15

catalog :

4527

quantity :

10 mg (also 50 mg)

price :

266 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Li Q, Deng Q, Chao H, Liu X, Lu Y, Lin K, et al. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun. 2018;9:3600 pubmed publisher
Baghdadi M, Castel D, Machado L, Fukada S, Birk D, Relaix F, et al. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature. 2018;557:714-718 pubmed publisher

product information

brand :

Tocris

master code :

4527

SKU :

4527/10

product name :

TC-I 15

description :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

target :

Integrin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

520.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent 2 1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). Displays selectivity for 2 1 over v 3, 5 1, 6 1 and IIb 3 at concentrations exceeding 1000 nM. Reduces collagen IV production in mesangial cells. Active in vivo ; prevents ferric chloride-induced clot formation in mice.

catalog number base :

4527

product keywords :

TC-I15 integrins receptors a2b1 alpha2beta1 2 1 inhibitors inhibits potent selective active in vivo antithrombotics collagen Integrins Cell Adhesion Molecules 4527,

extended description :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

chemical name text :

N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

formula :

C 23 H 28 N 4 O 6 S 2

formula text :

C23H28N4O6S2

cas num :

916734-43-5

2020 USD :

255

2021 USD :

266 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage