4527/10 | Tocris Bioscience 4527/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4527/10

catalog :

4527/10

quantity :

10 mg (also 50 mg)

price :

340 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Hunter E, Hamaia S, Gullberg D, Malcor J, Farndale R. Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol Appl Pharmacol. 2021;428:115669 pubmed publisher
Huang Y, Liang C, Ritz D, Coelho R, Septiadi D, Estermann M, et al. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. elife. 2020;9: pubmed publisher
Li Q, Deng Q, Chao H, Liu X, Lu Y, Lin K, et al. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun. 2018;9:3600 pubmed publisher
Baghdadi M, Castel D, Machado L, Fukada S, Birk D, Relaix F, et al. Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature. 2018;557:714-718 pubmed publisher

product information

master code :

4527

SKU :

4527/10

product name :

TC-I 15

unit size :

10 mg (also 50 mg)

description :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

target :

Integrin Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

520.62

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TC-I 15 is a potent 2 1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for 2 1 over v 3, 5 1, 6 1 and IIb 3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo ; TC-I 15 prevents ferric chloride-induced clot formation in mice.

top caption :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

extended description :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

chemical name text :

N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

formula :

C23H28N4O6S2

formula text :

C23H28N4O6S2

cas num :

916734-43-5

USD :

340 USD

product details :

Potent 2 1 inhibitor; displays antithrombotic activity in vivo

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage