Piclamilast | Tocris Bioscience 4525 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Piclamilast

catalog :

4525

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zhang H, Pan B, Wu P, Parajuli N, Rekhter M, Goldberg A, et al. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Sci Adv. 2019;5:eaaw5870 pubmed publisher

product information

brand :

Tocris

master code :

4525

SKU :

4525/10

product name :

Piclamilast

description :

Potent and selective PDE4 inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

381.25

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays 19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

catalog number base :

4525

product keywords :

RP73401 phosphodiesterases pde4 potent selective inhibitors inhibits RP 73401 Phosphodiesterases 4525,

extended description :

Potent and selective PDE4 inhibitor

chemical name text :

3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide

formula :

C 18 H 18 Cl 2 N 2 O 3

formula text :

C18H18Cl2N2O3

cas num :

144035-83-6

2020 USD :

212

2021 USD :

219 USD

alt names :

RP 73401

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage