4525/10 | Tocris Bioscience 4525/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4525/10

catalog :

4525/10

quantity :

10 mg (also 50 mg)

price :

275 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhang H, Pan B, Wu P, Parajuli N, Rekhter M, Goldberg A, et al. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Sci Adv. 2019;5:eaaw5870 pubmed publisher
Wang T, El Meouche I, Dunlop M. Bacterial persistence induced by salicylate via reactive oxygen species. Sci Rep. 2017;7:43839 pubmed publisher

product information

master code :

4525

SKU :

4525/10

product name :

Piclamilast

unit size :

10 mg (also 50 mg)

description :

Potent and selective PDE4 inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

381.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays 19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

top caption :

Potent and selective PDE4 inhibitor

extended description :

Potent and selective PDE4 inhibitor

chemical name text :

3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide

formula :

C18H18Cl2N2O3

formula text :

C18H18Cl2N2O3

cas num :

144035-83-6

USD :

275 USD

product details :

Potent and selective PDE4 inhibitor

alt names :

RP 73401

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage