EGCG | Tocris Bioscience 4524 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EGCG

catalog :

4524

quantity :

50 mg

price :

65 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Xue C, Tran J, Wang H, Park G, Hsu F, Guo Z. Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R Soc Open Sci. 2019;6:190179 pubmed publisher
Wei R, Penso N, Hackman R, Wang Y, MacKenzie G. Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. Nutrients. 2019;11: pubmed publisher
Daniels M, Nourse J, Kim H, Sainati V, Schiavina M, Murrali M, et al. Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity. Sci Rep. 2019;9:2937 pubmed publisher
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher
Eom D, Lee J, Kim Y, Hwang G, Kim S, Kwak J, et al. Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. BMB Rep. 2015;48:461-6 pubmed

product information

brand :

Tocris

master code :

4524

SKU :

4524/50

product name :

EGCG

description :

-secretase (BACE) inhibitor; inhibits amyloid assembly

target :

Amyloid beta Peptide Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

458.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

-secretase (BACE1) inhibitor (IC50 = 1.6 M); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as A , -synuclein and huntingtin. Reduces A 42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

catalog number base :

4524

product keywords :

BACE1 inhibitors inhibits -secretase b-secretase beta-secretase flavonoids green tea antioxidants neuroprotective EGCG epigallocatechin gallate amyloid assembly amyloidbeta amyloidb amyloid glutamate dehydrogenase GDH DNMT DNA Methyltransferas Epigallocatechin gallate Amyloid Beta Peptides DNA Methyltransferases Other Proteases 4524,

extended description :

-secretase (BACE) inhibitor; inhibits amyloid assembly

chemical name text :

3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

formula :

C 22 H 18 O 11

formula text :

C22H18O11

cas num :

989-51-5

2020 USD :

2021 USD :

65 USD

alt names :

Epigallocatechin gallate

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage