4523/50 | Tocris Bioscience 4523/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4523/50

catalog :

4523/50

quantity :

50 mg

price :

81 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Cai R, Tang J, Chen X. Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel. iScience. 2021;24:103395 pubmed publisher
Rastogi S, Ellinwood S, Augenstreich J, Mayer Barber K, Briken V. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. PLoS Pathog. 2021;17:e1009712 pubmed publisher
Colbourn R, Hrabe J, Nicholson C, Perkins M, Goodman J, HRABETOVA S. Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter. J Physiol. 2021;599:3195-3220 pubmed publisher
Lowin T, Tingting R, Zurmahr J, Classen T, Schneider M, Pongratz G. Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell Death Dis. 2020;11:714 pubmed publisher
Sim K, Lee Y, Kim H, Cho C, Yi G, Park M, et al. Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression. Cells. 2020;9: pubmed publisher
Kanda H, Ling J, Tonomura S, Noguchi K, Matalon S, Gu J. TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves. Neuron. 2019;104:960-971.e7 pubmed publisher
Khakipoor S, Giannaki M, Theparambil S, Zecha J, Kuster B, Heermann S, et al. Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR. Glia. 2019;67:2264-2278 pubmed publisher
Roebber J, Roper S, Chaudhari N. The role of the anion in salt (NaCl) detection by mouse taste buds. J Neurosci. 2019;: pubmed publisher
Cao Q, Zhao K, Zhong X, Zou Y, Yu H, Huang P, et al. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Biol Chem. 2014;289:23189-99 pubmed publisher
Harper M, Poole A. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. Cell Death Dis. 2013;4:e969 pubmed publisher

product information

master code :

4523

SKU :

4523/50

product name :

DIDS

unit size :

50 mg

description :

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

target :

Buffers, Chelators and Reagents

category :

Small Molecules

purity :

95%

observed molecular weight :

498.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 M). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 M in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 M).

top caption :

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

extended description :

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

chemical name text :

4,4 -Diisothiocyanato-2,2 -stilbenedisulfonic acid disodium salt

formula :

C16H8N2Na2O6S4

formula text :

C16H8N2Na2O6S4

cas num :

67483-13-0

USD :

81 USD

product details :

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage