4519/10 | Tocris Bioscience 4519/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4519/10

catalog :

4519/10

quantity :

10 mg (also 50 mg)

price :

232 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Vicente Baz J, Lopez Garcia J, Rivera Arconada I. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology. 2016;109:131-138 pubmed publisher
Brueggemann L, Haick J, Cribbs L, Byron K. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014;86:330-41 pubmed publisher

image

image 1 :

Cat.No. 4519 - ML 213 C17H23NO CAS No. 489402-47-3

product information

master code :

4519

SKU :

4519/10

product name :

ML 213

unit size :

10 mg (also 50 mg)

description :

KV7.2 and KV7.4 channel opener

target :

Voltage-gated Potassium Channel Activators

category :

Small Molecules

purity :

99%

observed molecular weight :

257.37

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membrane potential in an in vitro spinal cord preparation.

top caption :

KV7.2 and KV7.4 channel opener

extended description :

KV7.2 and KV7.4 channel opener

chemical name text :

N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide

formula :

C17H23NO

formula text :

C17H23NO

cas num :

489402-47-3

USD :

232 USD

product details :

KV7.2 and KV7.4 channel opener

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage