EPPTB | Tocris Bioscience 4518 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EPPTB

catalog :

4518

quantity :

10 mg (also 50 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4518

SKU :

4518/10

product name :

EPPTB

description :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

target :

Miscellaneous Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

378.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

catalog number base :

4518

product keywords :

Parkinson's disease trace amine-associated receptors 1 TAAR1 antagonists dopamine neurons neurones TA1 Trace Amine 1 Receptor 4518,

extended description :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

chemical name text :

N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide

formula :

C 20 H 21 F 3 N 2 O 2

formula text :

C20H21F3N2O2

cas num :

1110781-88-8

2020 USD :

164

2021 USD :

168 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage