4518/10 | Tocris Bioscience 4518/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4518/10

catalog :

4518/10

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 4518 - EPPTB C20H21F3N2O2 CAS No. 1110781-88-8

product information

master code :

4518

SKU :

4518/10

product name :

EPPTB

unit size :

10 mg (also 50 mg)

description :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

target :

Trace Amine 1 (TA1) Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

378.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

top caption :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

extended description :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

chemical name text :

N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide

formula :

C20H21F3N2O2

formula text :

C20H21F3N2O2

cas num :

1110781-88-8

USD :

216 USD

product details :

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage