4517/10 | Tocris Bioscience 4517/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4517/10

catalog :

4517/10

quantity :

10 mg (also 50 mg)

price :

230 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Xu X, Yan Q, Liu X, Li P, Li X, Chen Y, et al. 17β-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine γ-lyase. J Biol Chem. 2019;294:15577-15592 pubmed publisher
Ezpeleta J, Boudet Devaud F, Pietri M, Baudry A, Baudouin V, Alleaume Butaux A, et al. Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase. Sci Rep. 2017;7:7671 pubmed publisher

product information

master code :

4517

SKU :

4517/10

product name :

NS 2028

unit size :

10 mg (also 50 mg)

description :

Potent soluble guanylyl cyclase (sGC) inhibitor

target :

Guanylyl Cyclase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

269.05

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

top caption :

Potent soluble guanylyl cyclase (sGC) inhibitor

extended description :

Potent soluble guanylyl cyclase (sGC) inhibitor

chemical name text :

8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

formula :

C9H5BrN2O3

formula text :

C9H5BrN2O3

cas num :

204326-43-2

USD :

230 USD

product details :

Potent soluble guanylyl cyclase (sGC) inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage