4515/50 | Tocris Bioscience 4515/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4515/50

catalog :

4515/50

quantity :

50 mg

price :

69 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Sofia Beas B, Gu X, Leng Y, Koita O, Rodriguez Gonzalez S, Kindel M, et al. A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding. Nat Commun. 2020;11:6218 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher

product information

master code :

4515

SKU :

4515/50

product name :

2-Deoxy-D-glucose

unit size :

50 mg

description :

Non-metabolizable glucose analog; inhibits glucose metabolism

target :

Mitochondrial Hexokinase Substrates

category :

Small Molecules

observed molecular weight :

164.16

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Deoxy- D -glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.

top caption :

Non-metabolizable glucose analog; inhibits glucose metabolism

extended description :

Non-metabolizable glucose analog; inhibits glucose metabolism

chemical name text :

2-Deoxy-D-arabino-hexose

formula :

C6H12O5

formula text :

C6H12O5

cas num :

154-17-6

USD :

69 USD

product details :

Non-metabolizable glucose analog; inhibits glucose metabolism

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage