JW 55 | Tocris Bioscience 4514/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JW 55

catalog :

4514/10

quantity :

10 mg (also 50 mg)

price :

267 USD

citations: 2

Reference
Okamoto K, Ohishi T, Kuroiwa M, Iemura S, Natsume T, Seimiya H. MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs. Oncotarget. 2018;9:35844-35855 pubmed publisher
Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus Hill M, Koni P, et al. Î²-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells. Cancer Res. 2015;75:656-665 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

4514

SKU :

4514/10

product name :

JW 55

Description :

Tankyrase inhibitor

target :

Tankyrase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

434.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of -catenin; inhibits the -catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro .

extended description :

Tankyrase inhibitor

chemical name text :

N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

formula :

C 25 H 26 N 2 O 5

formula text :

C25H26N2O5

cas num :

664993-53-7

USD :

267 USD

product details :

Tankyrase inhibitor

storage :

Store at +4°C