STF 083010 | Tocris Bioscience 4509 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

STF 083010

catalog :

4509

quantity :

10 mg (also 50 mg)

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Xu Y, Melo Cardenas J, Zhang Y, Gau I, Wei J, Montauti E, et al. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight. 2019;4: pubmed publisher
Chen D, Dixon B, Doycheva D, Li B, Zhang Y, Hu Q, et al. IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018;15:32 pubmed publisher
Ko J, Koh J, So J, Jeon Y, Kim H, Chung D. Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep. 2017;7:14940 pubmed publisher
Kim S, Joe Y, Kim H, Kim Y, Jeong S, Pae H, et al. Endoplasmic reticulum stress-induced IRE1Î± activation mediates cross-talk of GSK-3Î² and XBP-1 to regulate inflammatory cytokine production. J Immunol. 2015;194:4498-506 pubmed publisher

product information

brand :

Tocris

master code :

4509

SKU :

4509/10

product name :

STF 083010

description :

Inhibits IRE1 endonuclease activity

target :

IRE1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

317.38

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of IRE1 endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro ; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo . Does not alter IRE1 kinase activity.

catalog number base :

4509

product keywords :

STF083010 IRE1alpha IRE1a IRE1 inhibitors inhibits endonucleases RNases XBP mRNA splicing inositol requiring enzyme endoplasmic reticulum IRE1 4509,

extended description :

Inhibits IRE1 endonuclease activity

chemical name text :

N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

formula :

C 15 H 11 NO 3 S 2

formula text :

C15H11NO3S2

cas num :

307543-71-1

2020 USD :

185

2021 USD :

191 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage