ML 218 hydrochloride | Tocris Bioscience 4507 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 218 hydrochloride

catalog :

4507

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Pascual Caro C, Berrocal M, Lopez Guerrero A, Alvarez Barrientos A, Pozo Guisado E, Gutierrez Merino C, et al. STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl). 2018;96:1061-1079 pubmed publisher
Li Z, Li S, Hu L, Li F, Cheung A, Shao W, et al. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT. Afr J Tradit Complement Altern Med. 2017;14:241-252 pubmed publisher
Galvan A, Devergnas A, Pittard D, Masilamoni G, Vuong J, Daniels J, et al. Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys. ACS Chem Neurosci. 2016;7:1543-1551 pubmed

product information

brand :

Tocris

master code :

4507

SKU :

4507/10

product name :

ML 218 hydrochloride

description :

CaV3.x blocker

target :

Voltage-gated Calcium Channel Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

405.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. Orally active.

catalog number base :

4507

product keywords :

ML218 HCl CID45115620 T-type calcium channels CAV3.1 CAV3.2 CAV3.3 inhibitors inhibits selective Cav3.x Channels 4507, Voltage-gated calcium channel blocker, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel

extended description :

CaV3.x blocker

chemical name text :

3,5-Dichloro-N-[[(1 ,5 ,6-exo,6 )-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride

formula :

C 19 H 26 Cl 2 N 2 O.HCl

formula text :

C19H26Cl2N2O.HCl

cas num :

2319922-08-0

2020 USD :

218

2021 USD :

227 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage