4507/10 | Tocris Bioscience 4507/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4507/10

catalog :

4507/10

quantity :

10 mg (also 50 mg)

price :

285 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Chakraborty R, Hu H, Darido C, Vickery K, Ranganathan S. ML218 HCl Is More Efficient Than Capsaicin in Inhibiting Bacterial Antigen-Induced Cal 27 Oral Cancer Cell Proliferation. Int J Mol Sci. 2021;22: pubmed publisher
Laryushkin D, Maiorov S, Zinchenko V, Gaidin S, Kosenkov A. Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons. Int J Mol Sci. 2021;22: pubmed publisher
Pascual Caro C, Berrocal M, Lopez Guerrero A, Alvarez Barrientos A, Pozo Guisado E, Gutierrez Merino C, et al. STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl). 2018;96:1061-1079 pubmed publisher
Li Z, Li S, Hu L, Li F, Cheung A, Shao W, et al. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT. Afr J Tradit Complement Altern Med. 2017;14:241-252 pubmed publisher
Galvan A, Devergnas A, Pittard D, Masilamoni G, Vuong J, Daniels J, et al. Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys. ACS Chem Neurosci. 2016;7:1543-1551 pubmed
Odackal J, Sherpa A, Patel N, Colbourn R, HRABETOVA S. T-type calcium channels contribute to calcium disturbances in brain during hyponatremia. Exp Neurol. 2015;273:105-13 pubmed publisher

product information

master code :

4507

SKU :

4507/10

product name :

ML 218 hydrochloride

unit size :

10 mg (also 50 mg)

description :

CaV3.x blocker

target :

Cav3.x Channel Blockers

category :

Small Molecules

purity :

99%

observed molecular weight :

405.79

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson s disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

top caption :

CaV3.x blocker

extended description :

CaV3.x blocker

chemical name text :

3,5-Dichloro-N-[[(1 ,5 ,6-exo,6 )-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride

formula :

C19H26Cl2N2O.HCl

formula text :

C19H26Cl2N2O.HCl

cas num :

2319922-08-0

USD :

285 USD

product details :

CaV3.x blocker

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage