product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
4505/10
catalog :
4505/10
quantity :
10 mg (also 50 mg)
price :
322 USD
more info or order :
citations: 19
Reference
Meryet Figuière M, Vernon M, Andrianteranagna M, Lambert B, Brochen C, Issartel J, et al. Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel). 2021;13: pubmed publisher
Sokpor G, Kerimoglu C, Nguyen H, Pham L, Rosenbusch J, Wagener R, et al. Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner. Front Mol Neurosci. 2021;14:687581 pubmed publisher
Aros C, Paul M, Pantoja C, Bisht B, Meneses L, Vijayaraj P, et al. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020;30:2055-2064.e5 pubmed publisher
Gravesen E, Nordholm A, Mace M, Morevati M, Høgdall E, Nielsen C, et al. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications. PLoS ONE. 2018;13:e0201936 pubmed publisher
Rothberg J, Maganti H, Jrade H, Porter C, Palidwor G, Cafariello C, et al. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov. 2018;4:21 pubmed publisher
Kling J, Jordan M, Pitt L, Meiners J, Thanh Tran T, Tran L, et al. Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling. Front Immunol. 2018;9:483 pubmed publisher
Gatica Andrades M, Vagenas D, Kling J, Nguyen T, Benham H, Thomas R, et al. WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice. Blood Adv. 2017;1:1274-1286 pubmed publisher
Zinecker H, Ouaret D, Ebner D, Gaidt M, Taylor S, Aulicino A, et al. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget. 2017;8:106764-106777 pubmed publisher
Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. ?-Catenin Directs Nuclear Factor-?B p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Front Immunol. 2017;8:1086 pubmed publisher
Benoit Y, Mitchell R, Risueno R, Orlando L, Tanasijevic B, Boyd A, et al. Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017;24:833-844.e9 pubmed publisher
Gu Y, Wang Z, Shi J, Wang L, Hou Z, Guo X, et al. Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway. Cell Death Dis. 2017;8:e2878 pubmed publisher
Koopmans T, Crutzen S, Menzen M, Halayko A, Hackett T, Knight D, et al. Selective targeting of CREB-binding protein/?-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. Br J Pharmacol. 2016;173:3327-3341 pubmed publisher
Wang J, Tao Y, Ping Z, Zhang W, Hu X, Wang Y, et al. Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro. Sci Rep. 2016;6:23827 pubmed publisher
Long K, Moss L, Laursen L, Boulter L, ffrench Constant C. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun. 2016;7:10354 pubmed publisher
Corbett L, Mann J, Mann D. Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells. PLoS ONE. 2015;10:e0142794 pubmed publisher
Boulter L, Guest R, Kendall T, Wilson D, Wojtacha D, Robson A, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest. 2015;125:1269-85 pubmed publisher
King M, Lindberg M, Stodden G, Okuda H, Ebers S, Johnson A, et al. WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015;34:3452-62 pubmed publisher
Yang C, Wang H, Lin Y, Kumar K, Lin H, Chang C, et al. Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma. PLoS ONE. 2014;9:e99412 pubmed publisher
Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/?-catenin pathway. Chem Biol. 2014;21:530-540 pubmed publisher
image
image 1 :
Tocris Bioscience 4505/10 image 1
Inhibits TCF/ -catenin-mediated transcription
product information
master code :
4505
SKU :
4505/10
product name :
ICG 001
unit size :
10 mg (also 50 mg)
description :
Inhibits TCF/ -catenin-mediated transcription
target :
beta-Catenin Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
548.63
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ICG 001 is an inhibitor of TCF/ -catenin-mediated transcription. Selectively inhibits -catenin/CBP interaction; displays no effect on -catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
top caption :
Inhibits TCF/ -catenin-mediated transcription
extended description :
Inhibits TCF/ -catenin-mediated transcription
chemical name text :
(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
formula :
C33H32N4O4
formula text :
C33H32N4O4
cas num :
780757-88-2
USD :
322 USD
product details :
Inhibits TCF/ -catenin-mediated transcription
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK