4504/1 | Tocris Bioscience 4504/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4504/1

catalog :

4504/1

quantity :

1 mg

price :

327 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Cheng Y, Snavely A, Barrett L, Zhang X, Herman C, Frost D, et al. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021;36:109666 pubmed publisher

product information

master code :

4504

SKU :

4504/1

product name :

Chaetocin

unit size :

1 mg

description :

SUV39H1 inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

696.84

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 values are 0.8, 2.5 and 3 M for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively). Induces apoptosis in myeloma cell lines in vitro ; exhibits antiproliferative activity in a mouse myeloma model in vivo . . Chaetocin potently inhibits cell proliferation and colony formation in a wide range of cancer cell lines (IC50 of 2-10 nM) and inhibits tumor growth by deregulating HIF-1 -mediated angiogenesis. Sensitizes glioblastoma multiforme cells to pro-apoptotic agents. . Chaetocin is also an inhibitor of the oxidative stress remediation enzyme thioredoxin reductase (TrxR), and so induces oxidative stress. . In addition, Chaetocin promotes osteogenic differentiation through modulating Wnt/Beta-catenin signaling in mesenchymal stem cells. Chaetocin treatment increased osteogenic ability and reduced adipogenic ability.

top caption :

SUV39H1 inhibitor

extended description :

SUV39H1 inhibitor

chemical name text :

(3S,3 S,5aR,5aR,10bR,10 bR,11aS,11 aS)-2,2 ,3,3 ,5a,5 a,6,6 -octahydro-3,3 -bis(hydroxymethyl)-2,2 -dimethyl-[10b,10 b(11H,11 H)-bi3,11a-epidithio-11aH-pyrazino[1 ,2 :1,5]pyrrolo[2,3-b]indole]-1,1 ,4

formula :

C30H28N6O6S4

formula text :

C30H28N6O6S4

cas num :

28097-03-2

USD :

327 USD

product details :

SUV39H1 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage